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However, a 2013 meta-analysis found no significant side effects linked to fragment 176-191 when tested in randomized, double-blind, placebo-controlled studies, whether given intravenously or orally

44 RoosG.MessensJ

The Cmax and AUC of one of the active metabolites, 3,4-dihydro-cilostazol, which has 4 to 7 times the activity of cilostazol, were increased by 29% and 69%, respectively

Additionally, the decreased rate of retinopathy seen with the use of a combination of vitamin supplements including vitamin C, can explain the non-significant differences in the macular and Optic nerve thickness in diabetic patients with and without retinopathy, reported in the present study (Table 4) 38