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Additionally, Klebsiella pneumoniae infection may modulate the hosts immune regulatory function by altering the metabolites of the gut microbiota, such as short-chain fatty acids (SCFAs) (32)

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Furthermore, the literature is replete with insufficient concepts, such as inflammatory depression or immune-mediated depression, and the classification of depression on the basis of these flawed concepts further obfuscates the interpretation and understanding of the NIMETOX pathways in MDD