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Moreover, ROS can inhibit protein phosphatase PP2A by oxidizing cysteine residues at its active site, thereby reducing its catalytic activity (78)

A recent study reported that oral large dose deucravacitinib (30 mg/kg QD) showed the similar equivalent efficacy to ustekinumab rather than medium dose deucravacitinib (10 mg/kg QD) in IL-23-driven psoriasis-like model ( K17 activates the transcription factor STAT3 under induction of deleterious ROS production in keratinocytes along with Cyclin D1, leading to the hyperproliferation of keratinocytes ( TNF-, IL-6, IL-17 and IL-22 ( Our study also has some limitations

Cell culture For primary culture of adipose-derived stem cells (ADSCs), the lipoaspirates were washed with phosphate-buffered saline (PBS) and rested for 10 min at room temperature

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