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Although BMD is variable in T1DM and T2DM, prolonged hyperglycemia promotes changes in bone metabolism and destroys bone micro-architecture through multiple mechanisms, such as production of AGEs, inflammation, calcium and phosphorus metabolism disorders, and oxidative stress (112)

Conclusion: Exosomal miRNAs hold promise as biomarkers for predicting response to atezolizumab-bevacizumab therapy

To reveal lactates role in this dynamic process, researchers found that manipulating MCT1-mediated lactate transport led to notable effects

Wiesinger C, Kunze M, Regelsberger G, Forss-Petter S, Berger J (2013) Impaired very long-chain acyl-CoA beta-oxidation in human X-linked adrenoleukodystrophy fibroblasts is a direct consequence of ABCD1 transporter dysfunction