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We found that expression of GPX4 was reduced after Cys 2 starvation and erastin treatment, further proving that ferroptosis is a primary mechanism of GSH depletion-induced cell death in RPE (Fig

Haas-Kogan D, Indelicato D, Paganetti H, Esiashvili N, Mahajan A, Yock T, Flampouri S, MacDonald S, Fouladi M, Stephen K, Kalapurakal J, Terezakis S, Kooy H, Grosshans D, Makrigiorgos M, Mishra K, Poussaint TY, Cohen K, Fitzgerald T, Gondi V, Liu A, Michalski J, Mirkovic D, Mohan R , Perkins S, Wong K, Vikram B, Buchsbaum J, Kun L

Animals received BPC 157 once daily for 12 days at 100 ng/kg body weight or at 10 g/kg body weight in the low-dose and in the high-dose group, respectively, whereas the control group received physiological saline i.p

The precision concern is real at this concentration