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Membranes, especially those with an abundance of negatively charged lipids, are able to catalyze hiAPP transformation into an -helical structure, especially in the presence of free copper, which then leads to membrane penetration and pore formation (Sitton et al., 2025)

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Chemosphere 92(9):10771084 Zhang S, Rensing C, Zhu Y-G (2014) Cyanobacteria-mediated arsenic redox dynamics is regulated by phosphate in aquatic environments

This adverse effect can be prevented by prior treatment with mesna (mercaptoethane sulphonic acid), which possesses both a thiol group for cytoprotection and a highly polar sulphonic acid group, and results in high renal excretion and delivery of this cytoprotective molecule to the bladder epithelium