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To avoid maternal T cell activation against fetal antigens, trophoblasts regulate T cell function by expressing indoleamine 2, 3 dioxygenases (IDO), an enzyme that inhibits T cell proliferation by depleting tryptophan (6668)

66 , e2200248 (2022)

For example, the overexpression of SIRT1 can decrease the acetylation level of retinoblastoma protein (Rb) in Pkd1-deficient MEK cells but increase its phosphorylation level, regulating the proliferation signal of renal cystic epithelial cells, and accelerate the growth of cysts in ADPKD patients (Zhou et al., 2013)