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13,95,96 Disruption of metabolic pathways exacerbates inflammatory responses and oxidative stress

In a murine model of B16F10 melanoma expressing both VEGF-C and chicken ovalbumin (OVA), overexpression of VEGF-C in cancer cells promotes lymphangiogenesis in both primary tumors and TDLNs, leads to CD8+ T cell immune tolerance via LEC cross-presentation ( Figure 1 ), protects tumors against preexisting anti-cancer immunity, and promotes the local elimination of OVA-specific CD8+ T cells (93)

Yeast strains carrying a conditional mutation in Ero1 were compromised in their ability to form disulphide bonds in secreted proteins when grown at the nonpermissive temperature