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However, this simple Amyloid-hypothesis has been challenged in the recent years because of many observations in AD patients like: the lack of any correlation between the presence of amyloid-containing plaques and the clinical symptoms of AD, the findings that amyloid plaques were already present decades before the onset of clinical symptoms in AD, the failure of all AD-related treatment strategies to improve clinical symptoms even if AD-plaques were reduced, and the continuing neurodegeneration in AD brain even after removing Amyloid plaques by vaccination

In the meantime, a prudent approach involves maintaining clinical vigilance and tailoring surveillance to individual patient needs and emerging symptoms

J Hematol Oncol 11(1):83, 2018

Exp Biol Med 230:155170