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For B16F10 tumour-bearing C57/6N mice, mice were treated with PBS (a), Phe-BF 3 (b), TBS&RGD@AuNPs (c), 2-fPBA&anti-CD3@AuNPs (d), mixed AuNPs (e) or mixed AuNPs + Phe-BF 3 (f) for the single therapy

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Until there is published a peer-reviewed clinical study of a scientifically-sufficient number of MVD-affected dogs with enlarged hearts in each of the 200+ recognized breeds, the EPIC Study investigators and these ACVIM consensus panelists have no legs to stand upon when it comes to claiming that any single measurement can define heart enlargement in any dog of any breed