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Transgenerational consequences include increased white adipose depot weights, adipocyte hyperplasia and hypertrophy, and hepatic lipid accumulation (223, 229)

Bacteria interact with alveolar cells, such as alveolar epithelial cells and macrophages, which secrete cytokines and neutrophil chemokines and subsequently recruit additional immune cells from the pulmonary circulation to the site of infection

Current therapeutic strategies targeting these age-related perturbations include senolytic compounds, nutritional interventions, physical activity protocols, and heterochronic parabiosis approaches (407)

Therapeutically, FGF21 analogs are being explored as a new approach in the treatment of MASLD