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Disclosures: Teruo Miyazaki: Nothing to Disclose, Hajime Ueda: Nothing to Disclose, Tadashi Ikegami: Nothing to Disclose, Akira Honda: Nothing to Disclose 2074 HISTONE DEACETYLASE INHIBITOR MS-275 REDUCES LIVER INJURY, INFLAMMATION, AND FIBROSIS IN A MOUSE MODEL OF CHOLESTATIC LIVER DISEASE Tony (Chun-Cheng) Chiang 1 Donghun Shin 1 Shuchang Liu 1 Satdarshan (Paul) Monga 1 Kari Nejak-Bowen 1 , 1 University of Pittsburgh Background: Liver transplantation remains the sole life-extending option for patients suffering from end-stage cholestatic liver disease thus a therapeutic alternative is urgently needed

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