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167 Natural phenols like resveratrol have also exhibited efficacy in modulating multidrug resistance in tumor cells by reducing GSTs, for example, in doxorubicin-resistant Caco-2 cells

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Endothelial cells in the BBB also express a variety of efflux transporter proteins that drain various lipophilic molecules from the brain back into the bloodstream[19]

Mitochondria are critical for muscle function and although we have reported defects in muscle mitochondrial respiration during early cognitive decline, APOE4 -mediated effects on muscle mitochondria are unknown