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Cellular functions Unusually for such a large and well-studied gene family, the functions of many GSTs are, at best, poorly understood

For PMP exam prep and real-world projects alike, its important to understand the SD formula, where it applies, and how it supports better decision-making

Xu J, Wang Y, Li Y, Yang X, Zhang P, Hou H, et al

Using a redox-sensitive fluorescent reporter (Mrx1-roGFP2), flow cytometry, and transcriptomics, we found that macrophages with high oxidative phosphorylation (OXPHOS) and low glycolysis harbor reductive, drug-tolerant Mtb , whereas glycolytically active macrophages generate mitochondrial ROS via reverse electron transport, imposing oxidative stress on Mtb and enhancing drug efficacy