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By contrast, glycerol administration to Insr P1195L/ +/HFD mice evoked a larger increase in blood glucose levels compared with those of WT/HFD mice (Fig

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Organs 43 , E308E319 (2019)

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Ethics declarations Ethics approval and consent to participate The study protocol was approved by the ethics committee of Guilan University of Medical Sciences (IR.GUMS.REC.1400.197) in accordance with the World Medical Associations code of ethics (Declaration of Helsinki, revised in Brazil 2013), and registered at an ICMJE and WHO recognized registry of clinical trials (www.irct.ir) at 28/08/2021 (registration number: IRCT20200920048782N1)

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SLC25A12, SLC25A13, GOT1, and GOT2 levels increased with aging in the cerebral cortex, hippocampus, and cerebellum, while MDH2 levels increased with aging in the cerebral cortex and hippocampus ( To synthesize one molecule of the 16:0 fatty acid palmitate, 14 NADPH molecules are oxidized, while to synthesize one molecule of cholesterol, 18 to 19 molecules of NADPH are oxidized (Vance and Vance, 1996)

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