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The liver and bile duct are innervated by the common hepatic branches derived from the left vagus nerve, the neural signals from the central nervous system influence glucose, lipid, and protein metabolism in the liver

Am J Clin Nutr (2011) 93(5):106272

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Furthermore, KEGG pathway enrichment analysis demonstrated significant enrichment of purine metabolism, valine, leucine, and isoleucine biosynthesis, arginine biosynthesis, the pentose phosphate pathway (PPP), and histidine metabolism in LPS-induced pneumonia, while papain-induced pneumonia primarily enriched the one-carbon pool by folate, alanine aspartate, and glutamate metabolism, glycine, serine, and threonine metabolism, cysteine and methionine metabolism, and the PPP (Figures 2C, E)