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More serious but rare adverse events include pancreatitis (0.2% incidence), gallbladder disease requiring surgical intervention, and medullary thyroid carcinoma risk in genetically predisposed individuals (contraindicated in patients with personal or family history of MTC or MEN2 syndrome)

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A small fraction of APAP is converted by CYP2E1 into the highly reactive NAPQI, which is normally detoxified by GSH

Pharmacol Res 175:106033 Yang B et al (2024) Circ DENND4C inhibits pyroptosis and alleviates ischemia-reperfusion acute kidney injury by exosomes secreted from human urine-derived stem cells