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Given the enormous increase of digestive issues and daily stressors ( e.g

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Intraventricular infusions, however, have been unsuccessful due to the relatively small surface area of the cerebral spinal fluid, limiting the diffusion of anticancer drugs into the brain parenchyma (17)

Both cross the bloodbrain barrier and have been shown to lower nighttime cortisol by dampening the hypothalamicpituitaryadrenal (HPA) axis, which in turn reduces stressinduced awakenings