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As a result, mitochondria become increasingly inefficient, producing more ROS and RNS, perpetuating neuronal injury, microglial activation, and chronic inflammation

Food Science

Transcription factor binding site analysis revealed that hypermethylated sites associated with disease activity were enriched for binding sites of two repressive transcription factors, EZH2 and SUZ12

Oxidized phospholipids in tumor ferroptosis Oxidation of membrane phospholipids plays a key mechanistic role in ferroptosis, which is a form of cell death driven by massive intracellular lipid peroxidation