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A more distant archaeon TyrA that preferred PDH activity had a non-acidic Gln, whose substitution to Glu introduced ADH activity

further developed a reversible, cell-permeable fluorescent probe (M4) that enables the direct visualization of the spatial distribution and dynamic changes in labile Mn 2+ levels in living cells

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Hirsutinolide series inhibit Stat3 activity, modulate GCN1, MAP1B, Hsp105, G6PD, Vimentin, and importin 2 expression, and induce antitumor effects against human glioma