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192 K63-linked ubiquitination of Akt is required for Akt membrane translocation and activation

This is particularly valuable for addressing genes with defective proteins that are difficult to be targeted with conventional drugs, showing considerable potential in treating rare, chronic, infectious diseases and other metabolic disorders

Seminal oxidative stress markers Lipid peroxidation and intracellular reactive oxygen species (ROS) levels were measured using BODIPY 581/591 C11 and DCFH-DA probes, respectively, following standard protocols

Lapatinib, a well-known anti-cancer drug, has been traditionally reported to exert anti-tumor effect via modulating oxidative stress and a recent work illustrates the improvement of encephalomyelitis in rodent models after lapatinib treatment