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These beneficial effects of ZHTC on DCM are related to the regulation of the PI3K/AKT1/FOXO3a signaling pathway

doi: 10.1056/NEJM199607043350101 Summary Keywords anabolicandrogenic steroids, endocrine disruption, hypogonadism, hypothalamicpituitarygonadal axis, male infertility, testosterone misuse, young men Citation Kowalik K, Harasny P, Kaliczyska L, Reweda-Kwiatkowski K, Starzyski D, Pawlak M, Waloryszak A, Ptak M, Modrzejewski A and Lisman D (2026) Non-medical use of exogenous testosterone and anabolicandrogenic substances in young men: health, psychological, and fertility consequences

Background: the Schoenenberger and Monnier isolation The historical context for DSIP is the hypnogenic-substance research program that ran through European sleep laboratories from the 1960s into the 1970s