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The 2025 studys strong method gives a clearer picture than some older studies

Moreover, persistent hyperglycaemia triggers activation of the (NF-B) pathway and release of pro-inflammatory factors, leading to an imbalance between the pro- and anti-inflammatory networks, resulting in an increase in reactive oxygen species and the production of a large number of inflammatory mediators, which affects the functioning of the mitochondria and leads to neuronal damage and degeneration (29)

Therefore, knowledge of its mechanisms of action can help to develop personalized therapeutic approaches and combination treatments that target autophagic pathways

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