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Current therapeutic interventions face critical limitations including narrow treatment windows, restricted patient eligibility, and significant adverse effects, underscoring the urgent need for safe, effective adjunctive strategies applicable during extended recovery periods

Apoptosis, the quintessential programmed cell death process, primarily relies on the caspase family for initiation and is typically characterized by membrane contraction, chromatin concentration and apoptotic body formation (103)

However, more recent studies are limited ( GKT136901 and GKT137831 can inhibit NOX-1, NOX-4, and NOX-5 activities

Phase 1 clinical trial of Trametes versicolor in women with breast cancer