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8(3): 168181 Chemical and physical properties and potential mechanisms: melatonin as a broad spectrum antioxidant and free radical scavenger Tan DX, et al Curr Top Med Chem 2002 Feb

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Hyperpigmentation is a common, often harmless skin condition caused by an increase in melanin, the substance that is responsible for color (pigment)

For example, if a drug has a half - life of one hour and you start with a concentration of 100 mg/L in the bloodstream, after one hour, the concentration will drop to 50 mg/L