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Administration of NAC is the mainstay treatment and standard of care in paracetamol overdose, with the most benefit seen if initiated within the first 8 h from the time of paracetamol overdose[57,58]

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doi: 10.3390/nu15051254 [DOI] [PMC free article] [PubMed] [Google Scholar] 151.Osman B, Sunderland M, Devine EK, Thornton L, Jacka F, Teesson M

This was in confirmation of our earlier studies on different diabetic rat models ( At the center of the cellular response to oxidative stress is the keap 1-Nrf2-antioxidant response elements (ARE) pathway, which helps in the maintenance of cellular homeostasis and detoxification by regulating the expression of many antioxidant proteins (Yoh et al., 2008)