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The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy

The sub-threshold doses of HGF and Dihexa combined, however, appeared to produce an effect similar to the saturating doses of HGF and Dihexa (p 0.05 by one-way ANOVA followed by Tukey post hoc test) as shown in The Morris water maze, a hippocampal-dependent spatial learning task requiring rats to locate a pedestal hidden beneath the surface of the water by orienting themselves to extra-maze cues was employed to evaluate the impact of the HGF antagonist, Hinge, on the pro-cognitive effects of Dihexa

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Similarly, CUR inhibits CYP3A4 and induces P-gp, altering the bioavailability of calcium channel blockers (e.g., amlodipine) and beta-blockers (e.g., carvedilol) (80)