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Aspartame in rodents disrupts neurotransmission, exacerbates oxidative damage, and impairs learning through glutamatergic excitotoxicity and mitochondrial dysfunction [9]

Without supplementation, deficiency is nearly universal within 23 years People taking metformin long-term metformin use reduces B12 absorption by 1030% through calcium-dependent ileal uptake disruption [4] People taking PPIs or H2 blockers acid suppression impairs B12 release from food proteins

Chronic inflammation, dietary influences (such as elevated consumption of red meat or dairy), obesity, and carcinogenic exposure may potentially facilitate tumor development and advancement