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It is worth noting that hyperbilirubinemia caused by a variety of drugs is often seen as a symbol of deferred drug biotransformation and signs of drug-induced hepatic injury, so care should be taken to control the bilirubin concentration during the clinical application of drugs to induce a GS state

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In fact, B12 is so potent a factor in cell maturation that some of the original studies on it showed that cells in the bone marrow (where blood is manufactured) when deliberately deprived of B12 could mature in just a few hours when B12 was added