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261 When IT therapies are combined with ICIs, systemic immune-related adverse events (irAEs), such as hepatitis, pneumonitis, or thyroiditis, may occur, highlighting the need for adaptive dosing, step-up schedules, and close clinical monitoring

Of note, NAC has been used adjunctively with various pharmacotherapies, particularly SSRI medication, without negative interactions and appears to show benefit in some treatment refractory patients

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By inhibiting NNMT, 5-Amino-1MQ helps regulate energy metabolism, reduce fat storage, and enhance NAD+ levels, which are crucial for cellular energy production