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The exception worth mentioning is that very high-dose folic acid can mask vitamin B12 deficiency on laboratory testing (by correcting macrocytic anaemia even if B12 itself remains low)

It can also be found free-floating in a soluble form, albeit in much lower concentrations [33]

Therefore, further characterization of the polyubiquitin chains and identification of the modified residues in Chac1 might give new insights into understanding the post-translational regulation of Chac1