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Pegaptanib includes a 40 kDa polyethylene glycol (PEG) unit at the 5 end to aid in renal clearance, along with a 3-3-linked deoxythymidine residue to enhance resistance to nuclease degradation (106)

Pivotal phase 3 trials on HIV lipodystrophy showed an average 15-18 percent VAT reduction after 26 weeks, with effect maintenance at 52 weeks

This can lead to: Reduced muscle tone Increased body fat Slower recovery from workouts or stress Lower energy levels Changes in sleep quality Visible signs of aging in the skin While these changes are gradual, they often become noticeable over time

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