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BMC Endocr Disord (2021) 21:44

Sudlow and colleagues first described the most important drug-binding sites in 1975, after identifying two specific locations in subdomains IIA and IIIA based on patterns of fluorescent probe displacement by competitive drugs.18, 19 Albumin also possesses esterase capability, allowing it to hydrolyse ester bonds of bound drugs and subsequently modify their pharmacological effects