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Mechanistically, GADD45 directly bound to SIRT1 and inhibited its ubiquitination, thereby prolonging SIRT1 protein stability

Int J Radiat Oncol 57:S302-3, 2003

Thus, the results in Tables 2G and 2H suggest that the two assays used to evaluate the anti-oxidant activity are not always in agreement, indicating that it may be adviseable to perform both assays, before concluding with certainty the absence of the antioxidant potential