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Discussion The main findings of our study in swine are that while DM alone substantially impacts cardiac hemodynamics, with elevated cardiac pre- and afterload provoking elevated coronary blood flow at rest which compromises coronary flow reserve, but also maladaptive cardiac remodeling with diastolic, systolic, and mitochondrial dysfunction, the addition of CKD causes no or little additional compromise on these parameters

The growth hormone-insulin-like growth factor-I axis in the diagnosis and treatment of growth disorders

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Comprehensive mitochondrial metabolic shift during the critical node of seed ageing in rice