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C34 and C37 target an immunodominant patch allosterically exposed by E3 dissociation on E2 To circumvent the complexity arising from the compact and crosslinked distribution of Fab molecules on VLP vertices, we determined the monovalent complex structures of C34 and C37 Fab molecules with the E1E2 heterodimer

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5.4 Considerations for intranasal delivery IN delivery provides a non-invasive and accessible dosing route for medication administration, but it also has several concerns that necessitate careful consideration

Table 4 Comparison of the percent of subjects achieving the targeted cumulative busulfan exposure (cAUC) for three different dosing cohorts