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Dexamethasone could diminish melatonin synthesis by reducing the expression of the key enzymes such as tryptophan hydroxylase, arylalkylamine N-acetyltransferase and hydroxyindole- O -methyltransferase [163]

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From the perspective of nanotherapeutic intervention, the most actionable pathological mechanisms in epilepsy include excitationinhibition imbalance, GABAergic and glutamatergic dysregulation, circuit hyperexcitability, synaptic dysfunction, neuroinflammation, oxidative stress, and ion-channel-related abnormalities (Table 10) [136]

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