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This therapy is often considered part of an anti-aging and wellness strategy aimed at restoring internal balance and supporting long-term physical resilience

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It has been suggested that exogenous oxidative stress reduces the expression of nuclear RanGTPase-activating protein, which is essential for the nuclear import of cargo proteins and re-localisation of importin-, resulting in impaired nuclear import, and thereby the reduced GR function and corticosteroid responsiveness seen in patients with COPD [44]