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The review confirmed that in vitro, 5-Amino-1MQ significantly reduced intracellular 1-MNA, increased intracellular NAD+, and suppressed lipogenesis in adipocytes

Over a 28-day period, lean WT mice treated with either compound exhibited increased body weight, replicating results seen in the shorter 14-day study

In preclinical research, 5-Amino-1MQ is primarily investigated for its ability to inhibit NNMT activity, which may influence multiple interconnected metabolic pathways

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