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Here is the reasoning that Campbell and Dunaif gave for feeding the high-protein diet during the initiation period: Animals

Wang L , Tsutsumi S, Kawaguchi T, Nagasaki K, Tatsuno K, Yamamoto S, Sang F, Sonoda K, Sugawara M, Saiura A, Hirono S, Yamaue H, Miki Y, Isomura M, Totoki Y, Nagae G, Isagawa T, Ueda H, Murayama-Hosokawa S, Shibata T, Sakamoto H, Kanai Y, Kaneda A, Noda T, Aburatani H

Lezina, S

Mitochondrial ROS is important not only for apoptosis induction, but also for ferroptosis induction, 19,20,21 although the molecular switches that determine the bifurcation between these two different types of cell death remain elusive