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Sperm DNA fragmentation is a clinically validated predictor of pregnancy loss 51 , and its reduction from 8.3% (control) to 5.0% at 100 g/mL, approaching the 5% AI semen quality threshold, likely contributed to improved embryo survival following cervical insemination

However, the in vivo data from animal infection models show that activation of cytosolic cGAS- or RLR-mediated sensing pathways can induce a strong type I IFN response that appears to impair host resistance to mycobacterial infection, 14,44 suggesting that Mtb may exploit the host cytosolic surveillance pathways to facilitate its own growth

The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine

PMID: 41604576 Adv Sci (Weinh) Pigment Epithelium-Derived Factor Deficiency Impairs Hippocampal Glutamate Homeostasis and Cognitive Function by Downregulating Astrocytic GLT-1