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Goldenseal Common Names: goldenseal, yellow root, goldenroot, yellow pucoon Latin Names: Hydrastis canadensis Goldenseal is a plant native to the northeastern United States and southeastern Canada

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Notably, in most countries PAC is freely sold as an OTC drug, raising the risk of unintentional abuse and increased adverse effects ( No answer can be given to the above open questions because PAC efficacy/adverse effects, unlike most of the drugs repositioned for COVID-19 therapy, have not yet been evaluated in controlled clinical trials or analyzed through retrospective analyses