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10.1142/s0192415x15500627 171 ZhangY

An altered IGF1 receptor is present in human leukemic cells

IV administration offers clear advantages

In murine studies, deletion of the IGF-1R in skeletal muscle resulted in glucose intolerance issues ultimately leading to T2D at an early age, because, although they express insulin receptors, they cannot form hybrid or IGF-1 receptors [162]