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As smooth muscle content decreases and collagen content increases, the smooth muscle-to-collagen ratio declines, reducing cavernous elasticity and impairing the veno-occlusive mechanism required for erection (138140)

Am J Hypertens 23(12):13181325 Dauchet L et al (2006) Fruit and vegetable consumption and risk of coronary heart disease: a meta-analysis of cohort studies

451 Fisetin, another natural senolytic drug, has also been studied in the clinical stage (Table 3) for the treatment of age-related diseases, and its use is expected to lead to breakthroughs in the clinical research of senolytics

Similarly, genetic knockout of CBS impaired the growth of GOT1/2 deficient, but not parental tumors (Fig