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The findings were inconsistent in plasma where two studies reported higher activity in cases than controls [72, 81] and two reported lower activity [71, 83]

J Chromatog 642:1532 Levsen K, Schiebel H-M, Behnke B, Dotzer R, Dreher W, Elend M, Thiele H (2005) Structure elucidation of phase II metabolites by tandem mass spectrometry: an overview

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Your stomach acid breaks it down, your intestines try to absorb what's left, and finally, a fraction of the medication reaches your bloodstream