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[DOI] [PubMed] [Google Scholar] 34.Munoz ME, Galan AI, Palacios E

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Upon activation, CX3CR1-mediated chemotaxis induces a shift to an amoeboid shape, accompanied by upregulation of TREM2-dependent phagocytic receptors and P2X7R activation, triggering dynamic secretion of pro-inflammatory cytokines (e.g., IL-1, TNF-) or anti-inflammatory factors (e.g., IL-10, TGF-)

Alternatively, the reaction can be conducted in a liquid phase in the presence or absence of the test compound, the reaction products separated from unreacted components, and complexes detected