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Front Immunol (2020) 11:587

A significantly decreases GSH levels in MC65 nerve cells, increases nonenzymatic and enzymatic oxidation of arachidonic acid (COX, 5-LOX, 12-LOX, and 15-LOX), and increases mitochondrial ROS levels and total intracellular lipid peroxides

Finally, compared to the cerebral I/R group, Sert enhanced PI3K and mTOR expression, leading to inhibition of autophagy as indicated by decreased Beclin-1 and LC3II/I expression