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doi: 10.1093/humupd/dmv047 6 McGoldrickEStewartFParkerRDalzielSR

The traditional high-throughput screening methods have been far from meeting the needs of drug research and development, and the early-stage research and development strategies of small molecule compounds and natural products need the effective combination of many modern methods

Aberrant lipid metabolism sensitizes aggressive TNBC cells to ferroptosis Based on this evidence, we hypothesized that the lipid metabolism of the more aggressive cells does not impact the total amount of intracellular lipids but rather their composition and complexity, a proxy of desaturase activity