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Infection with SARS-CoV-2 has adverse outcomes for individuals with particular comorbid diseases, e.g., hypertension, obesity, type 2 DM, and other CVDs and this may be due to the presence of pre-existing ED and systemic inflammation in subjects with these conditions ( Cardiovascular/cardiometabolic comorbidities such as coronary artery disease (ischemic heart disease, coronary heart disease), hypertension, and DM dramatically increase the risk of in-hospital mortality in COVID-19 patients ( Thus SARS-CoV-2 infection may cause persistent CV symptoms following recovery from acute COVID-19 ( In a US study including more than 150 000 individuals, 1 year after SARS-CoV-2 infection, a significantly increased risk of a variety of CVDs, including heart failure, dysrhythmias, myocardial infarction, and stroke, independent of the severity of initial COVID-19 presentation was observed ( SARS-CoV-2 infection can cause significant vascular pathology, cardiac injury, and acute and chronic CV complications

Marxsen JH, Stengel P, Doege K, Heikkinen P, Jokilehto T, Wagner T, Jelkmann W, Jaakkola P, Metzen E

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therefore, drug repurposing may be the promising strategy targeting multiple mechanisms of action via the application of known drugs for new indications