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"We are beginning to grasp it through observations and computer simulations

The implication here is that decreased melatonin production due to the genetic variant may be causally involved in autism.[ref] Related article : ADHD Genes and Root Causes Irritable Bowel Syndrome: There have been several clinical trials using melatonin to help with IBS symptoms

Phytochemical components are more broadly available, tolerable, and presumably possess fewer negative effects in comparison to synthetic pharmaceutical medications, making them especially appealing for further exploitation and characterization for potential application in depression